Considering the rarity of both firearms and ammunition, as well as the amount of inventory space both take, melee weapons are the best all-purpose weapons, while firearms are only useful for clearing out hordes when you're cornered/surrounded and for taking on multiple runners. 22 Long Rifle and 9mm Parabellum will one-shot any zombie if it's a headshot. More pronounced in 'Realism' mode: even the otherwise weak. This makes it a fairly effective melee weapon.
Bare Your Midriff: The 'Badass' player model does this.On the other hand, they take up 1/3 of your inventory, lack the 'focus' mechanic that allows you to headshot any zombie if you stand still for 3 seconds, and in the case of the MAC-10, cannot be toggled to semi-auto, which means you could fire off a large burst of ammo without intending to. On one hand, they boast the highest mag capacity at 30 rounds, and are chambered in common pistol ammo. Awesome, but Impractical: The MP5 and MAC-10 automatic weapons.